One??pot synthesis of novel spiro??annelated pyrrole??containing heterocyclic systems from suitable synthons

M Artico, S Massa, A Mai, R Silvestri…

Index: Artico, M.; Massa, S.; Mai, A.; Silvestri, R. Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 1 p. 241 - 245

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Citation Number: 11

Abstract

Abstract New tetracyclic systems containing a pyrrolobenzodiazepine 5 or a pyrrolobenzotriazepine 6 moiety bounded by a spiro linkage to the piperidine nucleus are described. They have been synthesized by a simple reaction involving the interaction between proper aromatic amines and 4-oxopiperidines substituted or not at the 1-position in the presence of maleic acid as a catalyst. The synthesis of spiropyrrolo [1, 2-a] quinoxaline ...