Quinazoline and benzimidazole MCH-1R antagonists

…, D Norman, AG Roach, P Smith, M Wong…

Index: Arienzo, Rosa; Cramp, Sue; Dyke, Hazel J.; Lockey, Peter M.; Norman, Dennis; Roach, Alan G.; Smith, Phil; Wong, Melanie; Wren, Stephen P. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1403 - 1407

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Citation Number: 22

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro eADME profiles.