Tetrahedron Letters

Solvent-free tetrahydropyranylation (THP) of alcohols and phenols and their regeneration by catalytic aluminum chloride hexahydrate

VV Namboodiri, RS Varma

Index: Namboodiri, Vasudevan V; Varma, Rajender S Tetrahedron Letters, 2002 , vol. 43, # 7 p. 1143 - 1146

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Citation Number: 101

Abstract

A catalytic amount of aluminum chloride hexahydrate enables solvent-free tetrahydropyranylation (THP) of alcohols and phenols at moderate temperatures. A simple addition of methanol helps to regenerate the corresponding alcohols and phenols, thus rendering these protection and deprotection sequences as very efficient transformations at high substrate to catalyst ratios.

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