Structure–activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein–protein interaction inhibitors

…, E Papadopoulos, R Sahoo, E Kabha, H Chen…

Index: Takrouri, Khuloud; Chen, Ting; Papadopoulos, Evangelos; Sahoo, Rupam; Kabha, Eihab; Chen, Han; Cantel, Sonia; Wagner, Gerhard; Halperin, Jose A.; Aktas, Bertal H.; Chorev, Michael European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 361 - 377

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Citation Number: 10

Abstract

Abstract Protein–protein interactions are critical for regulating the activity of translation initiation factors and multitude of other cellular process, and form the largest block of untapped albeit most challenging targets for drug development. 4EGI-1,(E/Z)-2-(2-(4-(3, 4- dichlorophenyl) thiazol-2-yl) hydrazono)-3-(2-nitrophenyl) propanoic acid, is a hit compound discovered in a screening campaign of small molecule libraries as an inhibitor of ...