N 1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors

AI Hernández, O Familiar, A Negri…

Index: Coyle, Susan; Hallett, Allan; Munns, Michael S.; Young, Geoffrey T. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 522 - 528

Full Text: HTML

Citation Number: 19

Abstract

... Journal of Medicinal ... 26b) that also inhibit HSV-1 TK were able to reverse the cytostatic activity of 1-(β-d-arabinofuranosyl)thymine (Ara-T) and ganciclovir ... the following features: 11 (i) the nucleic base is crucial for the interaction of these inhibitors with the target enzyme(s) (eg, it ...

Related Articles:

On the allyl protection of the imidazole ring of histidine

[Malanda Kimbonguila; Boucida; Guibe; Loffet Tetrahedron, 1997 , vol. 53, # 37 p. 12525 - 12538]

Rapid and facile Lewis acid catalysed Boc protection of amines

[Sharma; Janardhan Reddy; Sree Lakshmi; Radha Krishna, Palakodety Tetrahedron Letters, 2004 , vol. 45, # 37 p. 6963 - 6965]

On the allyl protection of the imidazole ring of histidine

[Malanda Kimbonguila; Boucida; Guibe; Loffet Tetrahedron, 1997 , vol. 53, # 37 p. 12525 - 12538]

Indium (III) halides as new and highly efficient catalysts for N-tert-butoxycarbonylation of amines

[Chankeshwara, Sunay V.; Chakraborti, Asit K. Synthesis, 2006 , # 16 p. 2784 - 2788]

On the allyl protection of the imidazole ring of histidine

[Malanda Kimbonguila; Boucida; Guibe; Loffet Tetrahedron, 1997 , vol. 53, # 37 p. 12525 - 12538]

More Articles...