Copper??Catalyzed Aromatic Trifluoromethylation via Group Transfer from Fluoral Derivatives

H Kondo, M Oishi, K Fujikawa…

Index: Kondo, Hideaki; Oishi, Masahiro; Fujikawa, Kenichi; Amii, Hideki Advanced Synthesis and Catalysis, 2011 , vol. 353, # 8 p. 1247 - 1252

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Citation Number: 74

Abstract

Abstract Starting from a readily available fluoral derivative, catalytic aromatic trifluoromethylation has been successfully achieved. A small amount of copper (I) iodide- phenanthroline complex catalyzed the cross-coupling reactions of aryl/heteroaryl iodides with the O-silylated hemiaminal of fluoral (trifluoroacetaldehyde) to provide trifluoromethylated arenes in moderate to high yields.

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