Direct zincation of functionalized aromatics and heterocycles by using a magnesium base in the presence of ZnCl2

…, GC Clososki, SH Wunderlich, A Unsinn…

Index: Dong, Zhibing; Clososki, Giuliano C.; Wunderlich, Stefan H.; Unsinn, Andreas; Li, Jinshan; Knochel, Paul Chemistry - A European Journal, 2009 , vol. 15, # 2 p. 457 - 468

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Citation Number: 63

Abstract

Abstract A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF by using (TMP) 2 Mg⋅ 2 LiCl (TMP= 2, 2, 6, 6-tetramethylpiperamidyl) in the presence of ZnCl 2. The possible pathways of this metalation procedure as well as possible reactive intermediates are discussed. This experimental protocol expands the tolerance of functional groups and allows an efficient zincation of sensitive heterocycles ...