Ceric ammonium nitrate catalyzed aza-Michael addition of aliphatic amines to α, β-unsaturated carbonyl compounds and nitriles in water

R Varala, N Sreelatha, SR Adapa

Index: Varala, Ravi; Sreelatha, Nuvula; Adapa, Srinivas R. Synlett, 2006 , # 10 p. 1549 - 1553

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Citation Number: 52

Abstract

Abstract Ceric ammonium nitrate (3 mol%) efficiently catalyzes the aza-Michael reaction of amines with α, β-unsaturated carbonyl compounds in water to produce the corresponding β- amino carbonyl compounds in good to excellent yields (55-99%) for most of the compounds under mild conditions. The reaction is procedurally simple and displays limited chemoselectivity, as aromatic amines were found to be unreactive.