A soluble-polymer system for the asymmetric transfer hydrogenation of ketones

…, O Ichihara, M Whittaker, M Wills

Index: Hannedouche, Jerome; Clarkson, Guy J.; Wills, Martin Journal of the American Chemical Society, 2004 , vol. 126, # 4 p. 986 - 987

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Citation Number: 29

Abstract

The appropriate combination of methacrylate polymers permits the synthesis of a soluble polymer for use in ruthenium (II)-catalyzed asymmetric transfer hydrogenation reactions. Using a 7: 3 copolymer of a poly (ethylene glycol) ester and a hydroxyethyl ester, a derived ruthenium (II)/norephedrine complex catalyses reduction of acetophenone in up to 95% yield and 81% ee.