Synthesis of Internal Alkynes through the Pd??Catalyzed Coupling of Heteroaryl Halides with Terminal Alkynes

…, P Sun, Y Zhu, H Yang, D Liu, G Rong…

Index: Lu, Linhua; Yan, Hong; Sun, Peng; Zhu, Yan; Yang, Hailong; Liu, Defu; Rong, Guangwei; Mao, Jincheng European Journal of Organic Chemistry, 2013 , # 9 p. 1644 - 1648

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Citation Number: 6

Abstract

Abstract Sonogashira-type cross-couplings of functionalized heterocyclic halides with terminal alkynes were performed efficiently at room temperature. The heteroaryl halides were easily prepared from the corresponding heterocyclic compounds. The catalytic system tolerated a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. This reaction provides an efficient method for the direct ...