Guaiacol transprotection: replacement of the phenoxy isopropyl protecting function by acetyl

CM Williams, LN Mander

Index: Williams, Craig M.; Mander, Lewis N. Tetrahedron Letters, 2004 , vol. 45, # 4 p. 667 - 669

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Citation Number: 4

Abstract

A one-step method for the conversion of isopropyl protected guaiacols to the corresponding acetates is reported. Treating 6-substituted isopropyl protected guaiacols with trimethylsilyl trifluoromethanesulfonate in a mixture of acetic anhydride and acetonitrile affords 6- substituted guaiacol acetates in yields ranging from 35% to 99%.