Vinylogous carbinolamine tumor inhibitors. 23. Synthesis and antileukemic activity of bis [[(carbamoyl) oxy] methyl]-substituted pyrrolo [2, 1-a] isoquinolines, pyrrolo [1, …

WK Anderson, AR Heider, N Raju…

Index: Anderson, Wayne K.; Heider, Arvela R.; Raju, Natarajan; Yucht, Jeffery A. Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2097 - 2102

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Citation Number: 71

Abstract

A series of bis [[(carbamoyl) oxy] methyl]-substituted pyrrole-fused tricyclic heterocycles were synthesized by using 1, 3-dipolar cycloaddition reactions with a trifluoromethanesulfonate salt of an appropriate Resissert compound or with a mesoionic oxazolone intermediate. All of the bis (carbamates) were active in vivo against P388 lymphocytic leukemia with 5, 6- dihydrc-8-methoxy-l, 2-bis (hydroxymethyl) pyrrolo [2, la] isoquinoline bis [N-(2-propyl) ...