Total synthesis of the ocular age pigment A2-E: a convergent pathway

RXF Ren, N Sakai, K Nakanishi

Index: Ren; Sakai; Nakanishi Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3619 - 3620

Full Text: HTML

Citation Number: 52

Abstract

The autofluorescent age pigments (lipofuscin) which accumulate in the human retinal pigment epithelium (RPE) cells with age are considered to be responsible for causing various eye diseases including age-related macular degeneration (AMD), the leading cause of blindness in elderly people for which no remedy exists. 1 The prevalence associated with AMD among Americans above 40 years of age was estimated to be 9.2%, 2 and a rising ...