Substituted 3-benzylcoumarins as allosteric MEK1 inhibitors: design, synthesis and biological evaluation as antiviral agents

…, Y Niu, Y Wu, X Wang, Y Peng, J Sun, L Liang, P Xu

Index: Wang, Chao; Zhang, Hao; Xu, Fengrong; Niu, Yan; Wu, Yun; Wang, Xin; Peng, Yihong; Sun, Jing; Liang, Lei; Xu, Ping Molecules, 2013 , vol. 18, # 5 p. 6057 - 6091

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Citation Number: 3

Abstract

Abstract: In order to find novel antiviral agents, a series of allosteric MEK1 inhibitors were designed and synthesized. Based on docking results, multiple optimizations were made on the coumarin scaffold. Some of the derivatives showed excellent MEK1 binding affinity in the appropriate enzymatic assays and displayed obvious inhibitory effects on the ERK pathway in a cellular assay. These compounds also significantly inhibited virus (EV71) replication ...