Journal of fluorine chemistry

Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives

K Umezu, F Tabuchi, Y Kimura

Index: Journal of Fluorine Chemistry, , vol. 121, # 1 p. 97 - 99

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Citation Number: 7

Abstract

... Journal of Fluorine Chemistry. ... One fluorine out of three was selectively replaced to hydroxide from a mixture of 2,4,6-trifluorobenzoic acid (1e) (10.0 mmol), 99% NaOH (40.0 mmol) in NMP in 86.7% yield, mp 180.8–183.4 °C. The 60 MHz NMR (DMSO-d6 + CDCl 3 ) δ: 6.27 ...

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