Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

Y Yamazaki, K Abe, T Toma, M Nishikawa…

Index: Yamazaki, Yukiyoshi; Abe, Kazutoyo; Toma, Tsutomu; Nishikawa, Masahiro; Ozawa, Hidefumi; Okuda, Ayumu; Araki, Takaaki; Oda, Soichi; Inoue, Keisuke; Shibuya, Kimiyuki; Staels, Bart; Fruchart, Jean-Charles Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4689 - 4693

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Citation Number: 26

Abstract

A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure–activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.

Cyclizations of Thioureas with a Hydroxy Group at the β-Position of the N-Substituent. I. Reaction with Cupric Acetate

[Iwakura,Y. et al. Bulletin of the Chemical Society of Japan, 1970 , vol. 43, # 8 p. 2531 - 2535]

Copper-catalyzed Ullmann coupling under ligand-and additive-free conditions. Part 1: O-Arylation of phenols with aryl halides

[Chang, Joyce Wei Wei; Chee, Sheena; Mak, Shiya; Buranaprasertsuk, Pongchart; Chavasiri, Warinthorn; Chan, Philip Wai Hong Tetrahedron Letters, 2008 , vol. 49, # 12 p. 2018 - 2022]

The Cleavage of β-Oxypropionitriles with Lithium Aluminum Hydride1

[Soffer; Parrotta Journal of the American Chemical Society, 1954 , vol. 76, p. 3580,3583]

Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

Abstract

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