Tetrahedron Letters

Room temperature synthesis of tri-, tetrasubstituted imidazoles and bis-analogues by mercaptopropylsilica (MPS) in aqueous methanol: application to the synthesis of …

C Mukhopadhyay, PK Tapaswi, MGB Drew

Index: Mukhopadhyay, Chhanda; Tapaswi, Pradip Kumar; Drew, Michael G.B. Tetrahedron Letters, 2010 , vol. 51, # 30 p. 3944 - 3950

Full Text: HTML

Citation Number: 54

Abstract

The heterogeneous solid catalyst, mercaptopropylsilica (MPS), has been prepared by a modified procedure in water and its structure confirmed by solid state carbon-13 CP-MAS NMR spectrum. This catalyst has been efficiently utilized for the synthesis of a wide variety of tri-, tetrasubstituted imidazoles and their bis-analogues at room temperature. The protocol was further explored for the synthesis of the drug trifenagrel.

Related Articles:

Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno [1, 2-c] isoquinolin-5, 11-diones

[Ahn, Gang; Schifano-Faux, Nadege; Goossens, Jean-Francois; Baldeyrou, Brigitte; Couture, Axel; Grandclaudon, Pierre; Lansiaux, Amelie; Ryckebusch, Adina Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2259 - 2263]

Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases

[Wada, Akimori; Kanatomo, Shoichi; Nagai, Sotoo Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1016 - 1022]

Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases

[Wada, Akimori; Kanatomo, Shoichi; Nagai, Sotoo Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1016 - 1022]

More Articles...