Silver??Catalyzed Cyclization of N??(Prop??2??yn??1??yl) pyridin??2??amines

…, J Marco??Contelles, A Samadi

Index: Chioua, Mourad; Soriano, Elena; Infantes, Lourdes; Jimeno, M. Luisa; Marco-Contelles, Jose; Samadi, Abdelouahid European Journal of Organic Chemistry, 2013 , # 1 p. 35 - 39

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Citation Number: 13

Abstract

Abstract We report herein the silver-catalyzed cycloisomerization of readily available N- (prop-2-yn-1-yl) pyridine-2-amines as a new and practical method for the synthesis of differently substituted 3-methylimidazo [1, 2-a] pyridines. The isomerization reactions proceeded under mild reactions conditions to give good yields and excellent regioselectivity. A DFT-based mechanistic analysis is also reported.