Structure–activity studies of 7-heteroaryl-3-azabicyclo [3.3. 1] non-6-enes: a novel class of highly potent nicotinic receptor ligands

SR Breining, M Melvin, BS Bhatti, GD Byrd…

Index: Breining, Scott R.; Melvin, Matt; Bhatti, Balwinder S.; Byrd, Gary D.; Kiser, Melanie N.; Hepler, Christopher D.; Hooker, Dawn N.; Zhang, Jenny; Reynolds, Leslie A.; Benson, Lisa R.; Fedorov, Nikolai B.; Sidach, Serguei S.; Mitchener, J. Pike; Lucero, Linda M.; Lukas, Ronald J.; Whiteaker, Paul; Yohannes, Daniel Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9929 - 9945

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Citation Number: 4

Abstract

The potential for nicotinic ligands with affinity for the α4β2 or α7 subtypes to treat such diverse diseases as nicotine addiction, neuropathic pain, and neurodegenerative and cognitive disorders has been exhibited clinically for several compounds while preclinical activity in relevant in vivo models has been demonstrated for many more. For several therapeutic programs, we sought nicotinic ligands with various combinations of affinity and ...