Synthesis and Antibiotic Activity of 1??Cycloalkoxymethyl??4??dimethylaminopyridinium and 1??[(1??Alkoxy) ethyl]??4??dimethylaminopyridinium Chlorides

…, L Michalak, J Krysinski, Z Kuncewicz

Index: Pernak; Michalak; Krysinski; Kuncewicz Archiv der Pharmazie, 1995 , vol. 328, # 6 p. 531 - 533

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Citation Number: 5

Abstract

Abstract DMAP reacts readily with chloromethylcycloalkyl ethers and α-chloroethyl alkyl ethers to give stable (1a–1e) and unstable (2a–2h) pyridinium chlorides. Reaction of these chlorides with NaOH produces the corresponding 4-pyridones. All the chlorides synthesized showed antibiotic activity. Particularly high activity against microbes representing cocci, rods, fungi, and bacilli was shown by 1-cyclododecyloxymethyl-4- ...