New strong fibrates with piperidine moiety.

…, H Hirota, M Otsuka, J Kotake, S Hasegawa…

Index: Komoto, Teruo; Hirota, Hiroyuki; Otsuka, Mari; Kotake, Jiro; Hasegawa, Susumu; Koya, Hidehiko; Sato, Susumu; Sakamoto, Takao Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1978 - 1985

Full Text: HTML

Citation Number: 12

Abstract

New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl] phenoxy]-2-methylpropanoic acid (9aA: AHL-157) showed very superior activities in decreasing triglyceride, cholesterol, and blood sugar compared to bezafibrate in mice and rats.

Related Articles:

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1, 2, 3, 6-tetrahydropyridines as 5-HT 2C agonists

[Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564]

Synthesis of 4-arylpiperidines from 1-benzyl-4-piperidone: application of the Shapiro reaction and alkenylsilane cross-coupling

[Morrill, Christie; Mani, Neelakandha S. Organic Letters, 2007 , vol. 9, # 8 p. 1505 - 1508]

Synthesis of the 1, 2, 3, 4??tetrahydrobenzofuro [2, 3??c] pyridine ring system

[Jaen, Juan C.; Wise, Lawrence D. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1317 - 1319]

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1, 2, 3, 6-tetrahydropyridines as 5-HT 2C agonists

[Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564]

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1, 2, 3, 6-tetrahydropyridines as 5-HT 2C agonists

[Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564]

More Articles...