ChemMedChem

Synthesis, Antitumor Evaluation and Docking Study of Novel 4??Anilinoquinazoline Derivatives as Potential Epidermal Growth Factor Receptor (EGFR) Inhibitors

GW Rao, GJ Xu, J Wang, XL Jiang, HB Li

Index: Rao, Guo-Wu; Xu, Geng-Jie; Wang, Jian; Jiang, Xu-Liang; Li, Hai-Bo ChemMedChem, 2013 , vol. 8, # 6 p. 928 - 933

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Abstract

Protein kinases, in particular receptor tyrosine kinases, are considered to be the second largest class of therapeutic targets by Gray et al.[1] The most extensively studied receptor tyrosine kinase is the epidermal growth factor receptor (EGFR).[2] Aberrant expression or activation of EGFR homologues has been connected with multiple human carcinomas, and drugs targeting ErbB activity have been licensed for treatment of lung, colon, breast, and ...