Synthesis of [14C] KT3??671, 2??Propyl??8??oxo??1??[(2′??(1H??[14C] tetrazole??5??yl) biphenyl??4??yl) methyl]??4, 5, 6, 7??tetrahydro??cycloheptimidazole, a novel potent …

…, T Yanagisawa, T Tomiyama

Index: Ueyama; Yanagisawa; Tomiyama Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 10 p. 915 - 919

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Abstract

Abstract 2-Propyl-8-oxo-1-[(2′-(1H-tetrazole-5-yl) biphenyl-4-yl) methyl]-4, 5, 6, 7- tetrahydrocyclohept imidazole (KT3-671), which has been found to be a potent and selective angiotesin II receptor antagonist, was synthesized in 14 C-labelled form by using potassium [14 C]-cyanide.[14 C](KT3-671) 9 with a specific activity of 1.74 GBq/mmol was prepared in four steps in 29.8% overall radio-chemical yield from potassium [14 C]-cyanide.

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Synthesis of [14C] KT3??671, 2??Propyl??8??oxo??1??[(2′??(1H??[14C] tetrazole??5??yl) biphenyl??4??yl) methyl]??4, 5, 6, 7??tetrahydro??cycloheptimidazole, a novel potent …

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