Friedel–Crafts acylation with amides

EK Raja, DJ DeSchepper, SO Nilsson Lill…

Index: Raja, Erum K.; Deschepper, Daniel J.; Nilsson Lill, Sten O.; Klumpp, Douglas A. Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5788 - 5793

Full Text: HTML

Citation Number: 18

Abstract

Friedel–Crafts acylation has been known since the 1870s, and it is an important organic synthetic reaction leading to aromatic ketone products. Friedel–Crafts acylation is usually performed with carboxylic acid chlorides or anhydrides, while amides are generally not useful substrates in these reactions. Despite being the least reactive carboxylic acid derivative, we have found a series of amides capable of providing aromatic ketones in ...

Related Articles:

Substituent effect in solvolysis of spiro [cyclopropane-1, 2'-indan]-1'-yl p-nitrobenzoate

[Ohkata, Katsuo; Akiyama, Masaki; Wada, Kenshi; Sakaue, Shun; Toda, Yoshiko; Hanafusa, Terukiyo Journal of Organic Chemistry, 1984 , vol. 49, # 14 p. 2517 - 2520]

2, 5-Dimethylphenacyl as a new photoreleasable protecting group for carboxylic acids

[Klan, Petr; Zabadal, Miroslav; Heger, Dominik Organic Letters, 2000 , vol. 2, # 11 p. 1569 - 1571]

An NMR investigation of the Mills-Nixon effect

[Australian Journal of Chemistry, , vol. 43, p. 1547 - 1557]

An NMR investigation of the Mills-Nixon effect

[Australian Journal of Chemistry, , vol. 43, p. 1547 - 1557]

The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist

[Baur, Francois; Beattie, David; Beer, David; Bentley, David; Bradley, Michelle; Bruce, Ian; Charlton, Steven J.; Cuenoud, Bernard; Ernst, Roland; Fairhurst, Robin A.; Faller, Bernard; Farr, David; Keller, Thomas; Fozard, John R.; Fullerton, Joe; Garman, Sheila; Hatto, Julia; Hayden, Claire; He, Handan; Howes, Colin; Janus, Diana; Jiang, Zhengjin; Lewis, Christine; Loeuillet-Ritzler, Frederique; Moser, Heinz; Reilly, John; Steward, Alan; Sykes, David; Tedaldi, Lauren; Trifilieff, Alexandre; Tweed, Morris; Watson, Simon; Wissler, Elke; Wyss, Daniel Journal of Medicinal Chemistry, 2010 , vol. 53, # 9 p. 3675 - 3684]

More Articles...