Novel lopinavir analogues incorporating non-Aromatic P-1 side chains—Synthesis and structure–Activity relationships

…, DA Betebenner, A Saldivar, S Vasavanonda…

Index: Sham, Hing L.; Zhao, Chen; Li, Leping; Betebenner, David A.; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J.; Plattner, Jacob J.; Norbeck, Daniel W. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3101 - 3103

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Citation Number: 35

Abstract

The HIV protease inhibitor Lopinavir has a pseudosymmetric core unit incorporating benzyl groups at both P-1, P-1′ positions. A series of analogues incorporating non-aromatic side chains at the P-1 position were synthesized and the structure–activity relationships explored.