Molecular recognition of L-leucyl-L-alanine: enantioselective inclusion of alkyl methyl sulfoxides

M Akazome, A Hirabayashi, K Takaoka, S Nomura…

Index: Akazome, Motohiro; Hirabayashi, Atsushi; Takaoka, Kousuke; Nomura, Satoru; Ogura, Katsuyuki Tetrahedron, 2005 , vol. 61, # 5 p. 1107 - 1113

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Citation Number: 20

Abstract

A simple aliphatic dipeptide, l-leucyl-l-alanine (Leu-Ala), includes several alkyl methyl sulfoxides enantioselectively to form inclusion crystals. From single-crystal X-ray analyses of three inclusion compounds of dimethyl sulfoxide (DMSO), isobutyl methyl sulfoxide, and benzyl methyl sulfoxide, it was elucidated that Leu-Ala molecules self-assemble to form layer structures and the sulfoxides are included via hydrogen bonding in a cavity between ...