Enantioselective Nucleophilic Catalysis: The Synthesis of Aza?螃漫?Lactams through [2+ 2] Cycloadditions of Ketenes with Azo Compounds

JM Berlin, GC Fu

Index: Berlin, Jacob M.; Fu, Gregory C. Angewandte Chemie - International Edition, 2008 , vol. 47, # 37 p. 7048 - 7050

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Citation Number: 59

Abstract

Even though aza-β-lactams have attracted interest because of their biological activity [1] and their utility as intermediates in organic chemistry (eg, for the generation of α-amino acids and hydantoins),[2–4] only limited progress has been reported with regard to the enantioselective synthesis of this family of heterocycles.[5] One attractive, convergent approach to the formation of aza-β-lactams is the [2+ 2] cycloaddition of a ketene with an ...