Design, synthesis and pharmacological evaluation of novel azole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents
M Amir, K Saifullah, W Akhter
Index: Amir, Mohammad; Saifullah, Khalid; Akhter, Wasim Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 1 p. 141 - 148
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Citation Number: 6
Abstract
A series of substituted azole derivatives (3a–e, 4a–e and 5a–e) were synthesised by the cyclisation of N1 (diphenylethanoyl)-N4-substituted phenyl thiosemicarbazides under various reaction conditions. These compounds were tested in vivo for their anti-inflammatory activity. The compounds which showed activity comparable to the standard drug ibuprofen, were screened for their analgesic, ulcerogenic and lipid peroxidation activities. The ...
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