Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations

…, J Deadman, D Jeevarajah, DI Rhodes

Index: Bremner, John B.; Keller, Paul A.; Pyne, Stephen G.; Robertson, Mark J.; Sakthivel; Somphol, Kittiya; Baylis, Dean; Coates, Jonathan A.; Deadman, John; Jeevarajah, Dharshini; Rhodes, David I. Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1265 - 1270

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Citation Number: 3

Abstract

Abstract The facile synthesis of seven new dicationic tripeptide benzyl ester derivatives, with hydrophobic group variations in the C-terminal amino acid component, is described. Moderate to good activity was seen against Gram-positive bacteria in vitro. One cyclohexyl- substituted compound 2c was tested more widely and showed good potency (MIC values ranging from 2–4 μg/mL) against antibiotic-resistant strains of Staphylococcus aureus and ...