Acta Chem Scand

Synthesis of strombine: a new method for monocarboxymethylation of primary amines

J Kihlberg, R Bergman, B Wickberg

Index: Kihlberg, Jan; Bergman, Rolf; Wickberg, Boerje Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1983 , vol. 37, # 10 p. 911 - 916

Full Text: HTML

Citation Number: 12

Abstract

Many common methods for monocarboxymethylation of primary amines give various amounts of dialkylated by-products. In this work the reaction of two equivalents of glyoxylic acid with representative primary aliphatic and aromatic amines, as well as with amino acids and a dipeptide, is shown to give only the N-(carboxymethyl)-iV*-formyl derivative of the amine under mild conditions in carboxylic acid solvents. Hydrolysis then produces the ...

Related Articles:

… Reaction of N-Aryl Sydnones with 2-Nitromethylenethiazolidine: Unexpected Formation of (Z)-2-(Nitro ((E)-p-substitutedphenyldiazenyl) methylene) thiazolidines

[Azarifar, Davood; Bosra, Hassan Ghasemnejad; Zolfigol, Mohammad-Ali; Tajbaksh, Mahmood Heterocycles, 2006 , vol. 68, # 1 p. 175 - 181]

Second-harmonic generation studies of chiral organic salts

[Borecka-Bednarz, Bozena; Bree, Alan V.; Patrick, Brian O.; Scheffer, John R.; Trotter, James Canadian Journal of Chemistry, 1998 , vol. 76, # 11 p. 1616 - 1632]

More Articles...