Syntheses of. alpha.-,. beta.-, and. gamma.-substituted carnitines via. beta.-keto esters

…, RN Comber, WJ Brouillette

Index: Comber, Robert N.; Hosmer, Carla A.; Brouillette, Wayne J. Journal of Organic Chemistry, 1985 , vol. 50, # 19 p. 3627 - 3631

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Citation Number: 14

Abstract

1 2 h, and provides 1 in 60% and 2 in 56% yields. We report herein a further improvement in the preparation of these important synthetic reagent^.^ Our synthesis, which is similar in concept but simpler in practice to a recent preparation of (3-halo acetal^,^ is based on three different reports in the literature:(1) the reported reaction of iodotrimethylsilane with a, p- unsaturated ketones to give 3-iodo enol silyl ethers:(2) the ability to employ ...