The Journal of Organic Chemistry

Gas-phase synthesis of nitriles

RJ Card, JL Schmitt

Index: Card, Roger J.; Schmitt, J. Lawrence Journal of Organic Chemistry, 1981 , vol. 46, p. 754 - 757

Full Text: HTML

Citation Number: 38

Abstract

n-Octanenitrile is obtained in 87% yield from the copper-catalyzed, gas-phase reaction of 1- octanol with ammonia at 325" C and 1 atm. Similar high yields of alkyl or aryl nitriles are obtained from the reaction of ammonia with primary alcohols, aldehydes, primary amines, secondary amines, and esters. The effect of reaction variables is examined: highest yields of nitriles are obtained when the reaction is carried out at ca. 300 OC and at ammonia to ...

Related Articles:

Weak Interactions Dominating the Supramolecular Self-Assembly in a Salt: A Designed Single-Crystal-to-Single-Crystal Topochemical Polymerization of a Terminal …

[Vidya Sagar Reddy; Venkat Rao; Subramanyam; Iyengar Synthetic Communications, 2000 , vol. 30, # 12 p. 2233 - 2237]

Catalytic hydrogenation of unactivated amides enabled by hydrogenation of catalyst precursor

[Tetrahedron Letters, , vol. 54, # 21 p. 2674 - 2678]

One-pot anti-Markovnikov hydroamination of unactivated alkenes by hydrozirconation and amination

[Strom, Alexandra E.; Hartwig, John F. Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8909 - 8914]

Synthesis of primary amines: first homogeneously catalyzed reductive amination with ammonia

[Gross, Thoralf; Seayad, Abdul Majeed; Ahmad, Moballigh; Beller, Matthias Organic Letters, 2002 , vol. 4, # 12 p. 2055 - 2058]

Sodium borohydride reactions under phase-transfer conditions: reduction of azides to amines

[Journal of Organic Chemistry, , vol. 47, # 22 p. 4327 - 4329]

More Articles...