Correlation between lipophilicity and reactivity under biomimetic conditions of β-hydroxybarbiturates

O LaFont, J Chastang, C Cavé, M Miocque

Index: Lafont; Chastang; Cave; Miocque European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 283 - 289

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Abstract

Abstract The effects of lipophilicity are studied on a chemical equilibrium between β- hydroxybarbiturates and corresponding allophanoyl γ-lactones under biomimetic conditions, in order to show that this physicochemical parameter is not only active in vivo on drug disposition, but also on the kinetics of chemical reactions.