Copper-catalyzed C sp2–H amidation of unactivated arenes by N-tosyloxycarbamates

A John, J Byun, KM Nicholas

Index: John, Alex; Byun, Jeena; Nicholas, Kenneth M. Chemical Communications, 2013 , vol. 49, # 93 p. 10965 - 10967

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Citation Number: 9

Abstract

Reports of direct C–H N-functionalization of arenes lacking activating/directing groups, however, are sparse and limited in substrate and N-reagent scope. 8 The direct conversion of benzene to aniline using redox active transition metal oxides with NH 3 /O 2 or hydroxylamine as N-reagents proceeds with moderate efficiency, but its substrate scope is unknown. 9 Transition metal-promoted arene amination by PhI NTs has been catalyzed by: (1) AuCl 3 10 and (2) ...