Tetrahedron Letters

Fe nano particles mediated C–N bond-forming reaction: Regioselective synthesis of 3-[(2-chloroquinolin-3-yl) methyl] pyrimidin-4 (3H) ones

SM Roopan, FRN Khan, BK Mandal

Index: Roopan, Selvaraj Mohana; Khan, Fazlur Rahman Nawaz; Mandal, Badal Kumar Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2309 - 2311

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Citation Number: 56

Abstract

An efficient and regioselective N-alkylation of 4 (3H)-pyrimidone with various electrophiles in the presence of Fe nano particle is reported. The catalyst initiates N-alkylation of amides by alkyl chlorides. The reaction of equimolar 4 (3H)-pyrimidone and 2-chloro-3-(chloromethyl) quinolines in the presence of KOH and Fe nano particle (5mol%) in DMSO solution under reflux condition formed 3-[(2-chloroquinolin-3-yl] methyl) pyrimidin-4 (3H) ones.