Biodegradable amphiphilic copolymer containing nucleobase: synthesis, self-assembly in aqueous solutions, and potential use in controlled drug delivery

H Kuang, S Wu, Z Xie, F Meng, X Jing…

Index: Kuang, Huihui; Wu, Suhong; Xie, Zhigang; Meng, Fanbo; Jing, Xiabin; Huang, Yubin Biomacromolecules, 2012 , vol. 13, # 9 p. 3004 - 3012

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Citation Number: 45

Abstract

Biodegradable nucleobase-grafted amphiphilic copolymer, the methoxyl poly (ethylene glycol)-b-poly (L-lactide-co-2-methyl-2 (3-(2, 3-dihydroxylpropylthio) propyloxycarbonyl)- propylene carbonate/1-carboxymethylthymine)(mPEG-bP (LA-co-MPT)), was synthesized. 1H NMR titration and FT-IR spectroscopy indicated that the hydrogen-bonding could be formed between mPEG-bP (LA-co-MPT) and 9-hexadecyladenine (A-C16). The ...