Determination of colchicine and colchiceine in microbial cultures by high-performance liquid chromatography

AE Klein, PJ Davis

Index: Klein, Allan E.; Davis, Patrick J. Analytical Chemistry, 1980 , vol. 52, # 14 p. 2432 - 2435

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Citation Number: 29

Abstract

Colchicine (1)) the major alkaloid of Colchicum species, has traditionally been employed for the treatment of gout (1). The antineoplastic activity of colchicine and its derivatives have recently increased interest in their potential use as chemotherapeutic agents (2). While colchicine itself may prove too toxic for use in this regard (3, 4), there is ample evidence to indicate that derivatives of colchicine exhibit a higher therapeutic index and, hence, hold ...