Synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl) vinyl] coumarins as lipoxygenase inhibitors

MG Kallitsakis, DJ Hadjipavlou-Litina, A Peperidou…

Index: Kallitsakis, Michael G.; Hadjipavlou-Litina, Dimitra J.; Peperidou, Aikaterini; Litinas, Konstantinos E. Tetrahedron Letters, 2014 , vol. 55, # 3 p. 650 - 653

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Citation Number: 3

Abstract

Abstract The synthesis of 4-hydroxy-3-[(E)-2-(6-substituted-9H-purin-9-yl) vinyl] coumarins has been achieved from the reactions of 4-hydroxycoumarin with 2-(6-substituted-9H-purin- 9-yl) acetaldehydes in DMF under heating. The new compounds showed significant lipoxygenase inhibitory activity (eg, 6a: IC 50= 6.25 μM).