Journal of the American Chemical Society

A β-Lactam with a Methylmercapto Substituent1

AD Holley, RW Holley

Index: Holley; Holley Journal of the American Chemical Society, 1951 , vol. 73, p. 3172

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Citation Number: 12

Abstract

The reaction of V with alkali has been demonstrated to involve hydrolysis of the 6-lactam to the amino acid. If, in the reaction of IV with alkali, the amino acid is the initial product, then clearly V is more reactive than IV. If, however, the reaction of IV with alkali takes place by some path other than the initial formation of the amino acid, then the rate of hydrolysis of IV to the amino acid must be even slower than that indicated by the rate of reaction with alkali ...

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