Design, synthesis and biological evaluation of nonpeptide integrin antagonists

…, JI Trujillo, B Jandeleit, K Chibale, M Rosenfeld…

Index: Nicolaou; Trujillo, John I.; Jandeleit, Bernd; Chibale, Kelly; Rosenfeld; Diefenbach; Cheresh; Goodman Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 8 p. 1185 - 1208

Full Text: HTML

Citation Number: 88

Abstract

Recent studies demonstrated that peptide and antibody antagonists of integrin αvβ3 block angiogenesis and tumor growth. In this article, the design, synthesis and biological evaluation of a series of nitroaryl ether-based, nonpeptide mimetics are described. The design of these compounds was based on Merck's arylether/α-aminoacid/guanidine framework and incorporates a novel nitroaryl system. The synthesized mimetics were ...