Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, …

WJ Shan, L Huang, Q Zhou, FC Meng, XS Li

Index: Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Meng, Fan-Chao; Li, Xing-Shu European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5885 - 5893

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Citation Number: 42

Abstract

A series of 9-N-substituted berberine derivatives were synthesized and biologically evaluated as antioxidant and inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase and amyloid-β aggregation. Most of these compounds exhibited very good antioxidant activities, inhibitive activities of AChE and amyloid-β aggregation. Among them, compound 8d,(o-methylphenethyl) amino linked at the 9-position of berberine, was ...

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