Antagonist, partial agonist, and full agonist imidazo [1, 5-a] quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor

RE TenBrink, WB Im, VH Sethy, AH Tang…

Index: TenBrink, Ruth E.; Im, Wha B.; Sethy, Vimala H.; Tang, Andrew H.; Carter, Don B. Journal of Medicinal Chemistry, 1994 , vol. 37, # 6 p. 758 - 768

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Citation Number: 128

Abstract

(4RS)-1-(5-Cyclopropyl-1, 2, 4-oxadiazol-3-y1)-12, 12a-dihydroimidazo [1, 5-a] pyrrolo [2, 1- c] quinoxalin-lO (llH)-one (la), 5-benzoyl-3-(5-cyclopropyl-1, 2, 4-oxadiazol-3-yl)-4, 5- dihydroimidazo [1, 5-alquinoxaline (13b), and tert-butyl (4S)-12, 12a-dihydroimidazo [l, 5- alpyrrolo [2, 1-clquinoxaline-1-carboxylate (le), as well as other imidazo [1, 5-alquinoxaline amides and carbamates, represent a new series of compounds which bind with high ...