Cyanoethylation. II. Cyanoethylation of 2-Thiazoline-2-thiol

RJ GAUL, WJ FREMUTH…

Index: Gaul,R.J. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 5106 - 5108

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Citation Number: 5

Abstract

It has been shown that the cyanoethylation of 4,5-dialkylthiazole-2-thiols (I, Fig. 1) occurs on the ring nitrogen rather than on the thiol sulfur at ~ m . ~ , ~ s SR RA ( ~ > s H -+ ... VI VI I VI11 t CII,=zCHCN Figure 1 This is somewhat surprising inasmuch as the for- mation of a Pthiazoline-3-propionitrile (11) de- stroys the aromaticity of the thiazole ring. Efros4& also reports, with reservation, that the cyanoethyla- tion of 2-mercaptobenzimidazole (IV) ...