A convenient method for insertion of the 5'-terminal phosphate group in the triester approach to oligoribonucleotide synthesis

…, M Kato, M Yoshida, R Yamaguchi

Index: Takaku, Hiroshi; Kato, Masaatsu; Yoshida, Masatoshi; Yamaguchi, Ryuichi Journal of Organic Chemistry, 1980 , vol. 45, # 16 p. 3347 - 3350

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Citation Number: 29

Abstract

0022-3263/80/1945-3347 $01.00/0 problems inherent in the phosphodiester method. However, only a few examples of the insertion of 5'-terminal phosphate residues in the phosphotriester approach to oligoribonucleotide synthesis" have been published. The native transfer ribonucleic acids (t-RNAs) contain a 5'-terminal phosphate. Consequently, the development of a convenient insertion of 5'-phosphate groups during the synthesis of ...