Tetrahedron letters

DDQ-mediated direct oxidative coupling of amides with benzylic and allylic sp 3 C–H bonds under metal-free conditions

D Ramesh, U Ramulu, K Mukkanti, Y Venkateswarlu

Index: Ramesh; Ramulu; Mukkanti; Venkateswarlu Tetrahedron Letters, 2012 , vol. 53, # 23 p. 2904 - 2908

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Citation Number: 12

Abstract

A simple and efficient method for the direct oxidative coupling of amides with benzylic and allylic sp3 C–H bonds using DDQ as an oxidant is described. A range of amides including benzamide, benzyl carbamate, and substituted sulfonamides reacted efficiently with various benzylic and allylic substrates under metal free conditions to afford amidation products in good to excellent yields.

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