Three??Component Synthesis of Amine Derivatives Using Benzylic and Allylic Alcohols as N??Alkylating Agents in the Absence of External Catalysts and Additives

HH Li, DJ Dong, SK Tian

Index: Li, Hai-Hua; Dong, De-Jun; Tian, Shi-Kai European Journal of Organic Chemistry, 2008 , # 21 p. 3623 - 3626

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Citation Number: 12

Abstract

Abstract The direct employment of benzylic and allylic alcohols as N-alkylating agents provides a useful synthetic route for amine derivatives by avoiding the preactivation of the hydroxy groups of alcohols. Herein we report a novel by-product-catalyzed three-component synthesis of amine derivatives from readily available benzylic and allylic alcohols, acyl chlorides (chloroformates or sulfonyl chlorides), and hexamethyldisilazane (HMDS). In the ...

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