Journal of Heterocyclic Chemistry

The synthesis and ring opening of N??substituted??2??oxo??6??azaspiro [2, 5] octanes

FD Popp, RF Watts

Index: Popp,F.D.; Watts,R.F. Journal of Heterocyclic Chemistry, 1978 , vol. 15, p. 675 - 676

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Citation Number: 7

Abstract

Abstract N-Substituted-4-piperidones have been reacted with trimethyl sulfoxonium iodide to give the title compounds. These undergo ring opening with lithium aluminum hydride- aluminum chloride to give piperidine-4-methanols which were converted to the chloromethylpiperidines.