Synthesis and antiviral activity of certain 4-substituted and 2, 4-disubstituted 7-[(2-hydroxyethoxy) methyl] pyrrolo [2, 3-d] pyrimidines

NK Saxena, BM Hagenow, G Genzlinger…

Index: Saxena; Hagenow; Genzlinger; Turk; Drach; Townsend Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1501 - 1506

Full Text: HTML

Citation Number: 34

Abstract

Results and Discussion Chemistry. The successful alkylations and glycosylations of pyrrolo [2, 3d] pyrimidines have been reported by using various conditions, eg, DMF/NaH, 21 phase- transfer conditions, 22 aqueous sodium hydroxide, 23 trimethyl-~ ilylation,~~ acid-catalyzed fusion procedure^,^^ etc. We elected to use the procedure recently reported for the stereospecific synthesis of various 2'-deoxynucleosides of pyrro10 [2, 3-d] pyrimidines.~~~ ...

Related Articles:

Preparation of 7??substituted pyrrolo [2, 3??d] pyrimidines and 9??substituted purines as potential antiparasitic agents

[LaMontagne, Maurice P.; Smith, David C.; Wu, Geng-Shuen Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 295 - 299]

Preparation of 7??substituted pyrrolo [2, 3??d] pyrimidines and 9??substituted purines as potential antiparasitic agents

[LaMontagne, Maurice P.; Smith, David C.; Wu, Geng-Shuen Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 295 - 299]

More Articles...