A one-pot preparation of N-2-mercaptobenzoyl-amino amides

RJ Bahde, DH Appella, WC Trenkle

Index: Bahde, Robert J.; Appella, Daniel H.; Trenkle, William C. Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4103 - 4105

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Abstract

Abstract The HIV-1 nucleocapsid (NCp7), structurally defined by zinc-binding domains, participates in crucial stages of the HIV-1 lifecycle and is mutationally nonpermissive, making it an attractive anti-HIV target. Mode of action studies have shown that the secondary structure and activity of NCp7 can be disrupted by acyl transfer from N-2-mercaptobenzoyl- amino amides. We have developed an improved one-pot reaction that affords N-2- ...