Thieno [2, 3-c] pyrazoles and related heterocycles

…, N Al-Mekhlafi, H El-Kashef

Index: Haider, Norbert; Farghaly, Abdel-Rahman; Al-Mekhlafi, Nabil; El-Kashef, Hussein Journal of Chemical Research, 2005 , # 12 p. 761 - 765

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Citation Number: 8

Abstract

5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde (1) was converted, via the oxime 2, into the chloronitrile 3. Treatment of compound 3 with methyl thioglycolate gave the novel methyl 4-amino-3-methyl-1-phenyl-1H-thieno [2, 3-c] pyrazole-5-carboxylate (4). This with 2, 5-dimethoxy-tetra-hydrofuran gave the pyrrolyl ester 5. Hydrazinolysis of the ester 5 gave the carbohydrazide derivative 6 which was used in the synthesis of substituted ...